Meclizine (Antivert, Antrizine, Ru-Vert-M, Meni-D)

Category:

• Antihistamine

Description:

• Antivertigo agent, antihistamine

Indications:

• Motion sickness

• “Possibly effective” in vertigo associated with diseases affecting vestibular system

Precautions:

• Pregnancy category B; used for nausea and vomiting during pregnancy

• Children <12 years

• Glaucoma, obstructive GI and GU disease

• Prostatic hypertrophy

Adverse Reactions (Side Effects):

• CNS: drowsiness, excitation (paradoxical reaction in children), restlessness

• CV: hypotension, palpitations, tachycardia

• EENT: blurred vision, diplopia, dry nose, dry throat

• GI: anorexia, constipation, diarrhea, dry mouth, nausea, vomiting

• GU: difficult urination, urinary frequency, urinary retension

• SKIN: rash urticaria

Dosage:

Administered orally (tablet, chewable tablet)

• Adult and Child >12 years:  

  • Motion sickness: PO 25-50mg 1 hour prior to travel; may repeat daily for duration of journey

  • Vertigo: PO 25-100mg daily in divided doses, usually 3 times daily