Medroxyprogesterone (Provera, Cycrin, Depo-Provera)

Category:

• Hormonal

Description:

• Progesterone hormone

Indications:

• Abnormal uterine bleeding (due to hormonal imbalance in the absence of organic pathology)

• Secondary amenorrhea

• Contraception

Contraindications:

• Current or history of thrombophlebitis, thromboembolic disorders, and cerebral apoplexy

• Liver impairment, known or suspected malignancy of the breast or genitalia

• Undiagnosed genital bleeding

• Missed abortion

• Use as a pregnancy diagnostic test

Precautions:

• Pregnancy category D (Provera and Cycrin)

• Pregnancy category X (Depo Provera)

• Use with caution in pregnant or nursing mothers

• Use with caution in patients with diabetes, epilepsy, migraine, asthma, cardiac or renal dysfunction, or history of depression.

• Injectable form of contraception has an extended duration of three months.

• Immediately discontinue therapy and consult health care provider if pregnancy is suspected.

Adverse Reactions (Side Effects):

• Rash, alopecia, acne, hirsutism

• Abnormal menstrual bleeding, changes in cervical secretions

• Edema, weight change

• Depression, insomnia, somnolence

• Nausea

• Injection site irritation

Dosage:

Administered orally or injection

• Abnormal uterine bleeding: 

  • 5-10mg daily for 5-10 days initiated on 16^th or 21^st day of cycle

• Secondary amenorrhea: 

  • 5-10mg daily for 5-10 days

• Contraception: 

  • 150mg IM injection (gluteal or deltoid muscle) every three months, given in first 5 days of normal menstrual cycle