Orphenadrine (Norflex, Banflex, Orfro, Orpenate)

Category:

• Skeletal Muscle Relaxant

Description:

• Skeletal Muscle Relaxant

Indications:

• Painful acute musculoskeletal conditions

• Quinine-resistant leg cramps (non FDA approved)

Contraindications:

• Glaucoma, pyloric or duodenal obstruction, stenosing peptic ulcer

• Prostatic hypertrophy, obstruction of bladder neck, cardiospasm, myasthenia gravis

Precautions:

• Pregnancy category C

• Children, cardiac decompensation

• Coronary insufficiency, cardiac dysrhythmia

• Tachycardia, sulfite sensitivity

Adverse Reactions (Side Effects):

• CNS: agitation, confusion, dizziness, drowsiness, hallucinations, headache, lightheadedness, tremor, weakness

• CV: palpitation, tachycardia, transient syncope

• EENT: blurred vision, increased ocular tension, pupil dilation

• GI: constipation, dry mouth, gastric irritation, nausea, vomiting

• GU: urinary hesitancy, urinary retention

• HEME: aplastic anemia (rare)

• SKIN: urticaria and other dermatoses

Dosage:

Administered orally, intramuscularly, intravenously

• Adult:   PO 100mg 2 times daily; IM/IV 60mg, may repeat every 12 hours as needed