Ampicillin with Sulbactam (Unisyn)

Category:

• Antibiotic

Description:

• Penicillin with beta-lactamase inhibitor

• 500mg of sulbactam per 1 gram of ampicillin

Indications:

• Mild to moderate infections (i.e.; skin, intra-abdominal and gynecological infections)

• susceptible strains of S. aureus, Klebsiella species, E. coli, H. influenzae, P. mirabilis, Bacteroides fragilis, Enterobacter species, Acinetobacter calcoaceticus

Contraindications:

• None

Precautions:

• Pregnancy category B

• Use with caution in patients with PCN or cephalosporin allergy (5-10% chance of cross-reactivity)

• Dosage modifications are generally only required in patients with severe renal impairment

Adverse Reactions (Side Effects):

• Hypersensitivity (rash not representing a true allergy)

• Gastrointestinal: nausea, vomiting, diarrhea

• Vaginitis

Dosage:

• Administered IV or IM (powder for injection)

• Adult:

  • 1.5-3 grams every 6 hours (not to exceed 4 grams per day of sulbactam component)

• Child (>1 year old or < 40kg):

  • 300mg/kg/day in divided doses every 6 hours

• Child (> 40kg):

  • adult dosing guidelines