Danazol (Danacrine)

Category:

  • Hormonal

Description:

  • Synthetic androgen

Indications:

  • Endometriosis

  • Fibrocystic breast disease

  • Hereditary angioedema

Contraindications:

  • Pregnancy and lactation

  • Undiagnosed vaginal bleeding

  • Markedly impaired hepatic, renal or cardiac function

Precautions:

  • Pregnancy category X

  • Rule out breast cancer prior to initiating treatment.

  • Begin endometriosis and fibrocystic breast disease therapy after ruling out pregnancy and during menstrual cycle.

  • May cause irreversible androgenic effects (hirsutism, decreased breast size, deepening of voice, clitoral hypertrophy)

Adverse Reactions (Side Effects):

  • Androgenic: acne, oily kin/hair, weight gain, mild hirsutism, decreased breast size, deepening of voice, clitoral hypertrophy, testicular hypotrophy

  • Hypoestrogenic: flushing, sweating, vaginitis, nervousness, emotional disorders

  • Hepatic dysfunction

  • CNS: dizziness, headache, sleep disorders, fatigue

  • Muscle cramps, joint pain and swelling

Dosage:

  • Administered orally

  • Mild Endometriosis: 

    • 200-400mg/day in two divided doses

  • Endometriosis: 

    • 800mg/day in two divided doses

  • Fibrocystic breast disease: 

    • 100-400mg/day in two divided doses

  • Hereditary angioedema: 

    • 200mg 2-3 times a day, decrease dose to individualized therapy

Source: Operational Medicine 2001,  Health Care in Military Settings, NAVMED P-5139, May 1, 2001, Bureau of Medicine and Surgery, Department of the Navy, 2300 E Street NW, Washington, D.C., 20372-5300  


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