Mezlocillin (Mezlin)

Category:

• Antibiotic

Description:

• Penicillin

Indications:

• Mild to moderate infections (i.e.; lower respiratory, intra-abdominal, urinary tract, uncomplicated gonorrhea, gynecological, skin, septicemia, streptococcal and pseudomonal infections)

• susceptible strains of H. influenzae, Klebsiella species, Pseudomonas species, Proteus mirabilis, E. coli, Enterobacter species, Streptococcus faecelis, Peptococcus species, Peptostreptococcus species, Bacteriodes species (including B. fragilis), Morganella morganii, Serratia  species, N. gonorrhoeae, P. vulgaris, Providencia rettgeri

Contraindications:

• None

Precautions:

• Pregnancy category B

• Use with caution in patients with PCN or cephalosporin allergy (5-10% chance of cross-reactivity)

Adverse Reactions (Side Effects):

• Hypersensitivity

• Gastrointestinal: nausea, diarrhea

• Vaginitis  

Dosage:

• Administered by IV or IM injection

• Adults:

  • 200-300mg/kg/day in 4-6 divided doses (usual dose 3gm q4h)

• Infants (> 1 month old) and Child:

  • 50mg/kg every 4 hours (300mg/kg/day)

• Neonates:

  • dosed based on age and weight